Since July 2011, I have been undertaking my 2nd post-doctoral position in the laboratory of Dr Mandi de Mestre. I have changed fields slightly, now working in early placental development, specifically equine binucleate chorionic girdle trophoblast differentiation.
I have recently elucidated a role for BMP4 in the paracrine regulation of terminal differentiation of and subsequent chorionic gonadotrophin (CG) secretion from trophoblast cells of the chorionic girdle via activation of the SMAD1/5/8 pathway. Furthermore, I have shown that when the SMAD 2/3 pathway is inhibited, BMP4 induced terminal differentiation of CG-secreting trophoblast cells is further increased (Cabrera-Sharp et al 2013, manuscript in review). This work was presented my myself at BES 2013 (prize abstract), SRF 2013 and SSR 2013 (oral communications).
This year (2013), I was awarded a Society for Endocrinology Early Career Grant which will allow me to investigate the translational aspects of my equine research to human medicine; collaborating with Mandi and Dr Judith Cartwright at St Georges.